Abstract
Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.
We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.
We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.
Original language | English |
---|---|
Type | preprint |
Publisher | Research Square |
Number of pages | 22 |
DOIs | |
Publication status | Published - 11 Oct 2023 |
Access to Document
10.21203/rs.3.rs-2982830/v1Licence: CC BY
Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver
Walsh, S., Siew, K., Afsari, F., Al-Jaber, M., Allen, N., Al-Maadheed, M., Altinok, S., Arif, S., Bah, N., Baranzini, S. E., Barker, P., Beheshti, A., Blaber, E., Border, S., Boyko, V., Broni-Tabi, J., Burling, K. A., Campbell, R., Cheng-Campbell, M., ... Zhong, C. (2023, Oct 11). Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. Research Square. https://doi.org/10.21203/rs.3.rs-2982830/v1
Walsh, Stephen ; Siew, Keith ; Afsari, Fatemeh et al. / Cosmic Kidney Disease : The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. 2023. Research Square. 22 p.
@misc{c56a672caef34a4c966aeaa46a2162de,
title = "Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function",
abstract = "Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts{\textquoteright} increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.",
author = "Stephen Walsh and Keith Siew and Fatemeh Afsari and Maneera Al-Jaber and Noah Allen and Mohammed Al-Maadheed and Selin Altinok and Shehbeel Arif and Nourdine Bah and Baranzini, {Sergio E} and Peter Barker and Afshin Beheshti and Elizabeth Blaber and Samuel Border and Valery Boyko and Jessica Broni-Tabi and Burling, {Keith A.} and Robert Campbell and Margareth Cheng-Campbell and Chris Cheshire and Lorianna Colon and Costes, {Sylvain V.} and Laura Cubitt and Viola D'Ambrosio and Lovorka Degoricija and Amelia Eisch and Hossein Fazelinia and Nichola Figg and Rebecca Finch and Jonathan Foox and Alison French and Jonathan Galazka and Samrawit Gebre and Peter Gordon and Alessandra Grillo and Nadia Houerbi and {Valipour Kahrood}, Hossein and Fathi Karouia and Frederico Kiffer and JangKeun Kim and Aleksandra Klosinska and Angela Kubik and Lee, {Han Chung} and Yinghui Li and Zhongwang Li and Nicholas Lucarelli and Steven Lynham and Anthony Marullo and Christopher Mason and Irina Matei and Cem Meydan and Sayat Mimar and Vidya Mohamed-Ali and Masafumi Muratani and Ahmed Naglah and Charlotte Nelson and Kevin Nestler and Jerome Nicod and Kevin O'Shaughnessy and {De Oliveira}, {Lorraine Christine} and Leah Oswalt and Eliah Overbey and Vaksha Patel and Patras, {Laura Ioana} and San-huei Polo and Mar{\'i}a Rodr{\'i}guez-Lopez and Samuel Rodriques and Candice Roufosse and Omid Sadeghi-Alavijeh and Rebekah Sanchez-Hodge and Sanders, {Lauren M.} and Anindya Sankar and Pinaki Sarder and Jonathan Schisler and Schittenhelm, {Ralf B.} and Annalise Schweickart and Ryan Scott and Dai Shiba and Terry Lim and Willian Silveira and Hubert Slawinski and Scott Smith and Daniel Snell and Julio Sosa and Joel Steele and Marshall Tabetah and Erwin Tanuwidjaya and Akira Uruno and Michael Vaughan and Simon Walker-Samuel and Elizabeth Wan and Masayuki Yamamoto and Xiaoping Yang and Yasmin Yasmin and Sanghee Yun and Hailey Zhang and Zhongquan Dai and Jasminka Zimmermann and Sara Zwart and Almeida, {Eduardo A.C.} and Chutong Zhong",
year = "2023",
month = oct,
day = "11",
doi = "10.21203/rs.3.rs-2982830/v1",
language = "English",
publisher = "Research Square",
type = "Other",
}
Walsh, S, Siew, K, Afsari, F, Al-Jaber, M, Allen, N, Al-Maadheed, M, Altinok, S, Arif, S, Bah, N, Baranzini, SE, Barker, P, Beheshti, A, Blaber, E, Border, S, Boyko, V, Broni-Tabi, J, Burling, KA, Campbell, R, Cheng-Campbell, M, Cheshire, C, Colon, L, Costes, SV, Cubitt, L, D'Ambrosio, V, Degoricija, L, Eisch, A, Fazelinia, H, Figg, N, Finch, R, Foox, J, French, A, Galazka, J, Gebre, S, Gordon, P, Grillo, A, Houerbi, N, Valipour Kahrood, H, Karouia, F, Kiffer, F, Kim, J, Klosinska, A, Kubik, A, Lee, HC, Li, Y, Li, Z, Lucarelli, N, Lynham, S, Marullo, A, Mason, C, Matei, I, Meydan, C, Mimar, S, Mohamed-Ali, V, Muratani, M, Naglah, A, Nelson, C, Nestler, K, Nicod, J, O'Shaughnessy, K, De Oliveira, LC, Oswalt, L, Overbey, E, Patel, V, Patras, LI, Polo, S, Rodríguez-Lopez, M, Rodriques, S, Roufosse, C, Sadeghi-Alavijeh, O, Sanchez-Hodge, R, Sanders, LM, Sankar, A, Sarder, P, Schisler, J, Schittenhelm, RB, Schweickart, A, Scott, R, Shiba, D, Lim, T, Silveira, W, Slawinski, H, Smith, S, Snell, D, Sosa, J, Steele, J, Tabetah, M, Tanuwidjaya, E, Uruno, A, Vaughan, M, Walker-Samuel, S, Wan, E, Yamamoto, M, Yang, X, Yasmin, Y, Yun, S, Zhang, H, Dai, Z, Zimmermann, J, Zwart, S, Almeida, EAC & Zhong, C 2023, Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. Research Square. https://doi.org/10.21203/rs.3.rs-2982830/v1
Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. / Walsh, Stephen; Siew, Keith; Afsari, Fatemeh et al.
22 p. Research Square. 2023, preprint.
Research output: Other contribution › Research
TY - GEN
T1 - Cosmic Kidney Disease
T2 - The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function
AU - Walsh, Stephen
AU - Siew, Keith
AU - Afsari, Fatemeh
AU - Al-Jaber, Maneera
AU - Allen, Noah
AU - Al-Maadheed, Mohammed
AU - Altinok, Selin
AU - Arif, Shehbeel
AU - Bah, Nourdine
AU - Baranzini, Sergio E
AU - Barker, Peter
AU - Beheshti, Afshin
AU - Blaber, Elizabeth
AU - Border, Samuel
AU - Boyko, Valery
AU - Broni-Tabi, Jessica
AU - Burling, Keith A.
AU - Campbell, Robert
AU - Cheng-Campbell, Margareth
AU - Cheshire, Chris
AU - Colon, Lorianna
AU - Costes, Sylvain V.
AU - Cubitt, Laura
AU - D'Ambrosio, Viola
AU - Degoricija, Lovorka
AU - Eisch, Amelia
AU - Fazelinia, Hossein
AU - Figg, Nichola
AU - Finch, Rebecca
AU - Foox, Jonathan
AU - French, Alison
AU - Galazka, Jonathan
AU - Gebre, Samrawit
AU - Gordon, Peter
AU - Grillo, Alessandra
AU - Houerbi, Nadia
AU - Valipour Kahrood, Hossein
AU - Karouia, Fathi
AU - Kiffer, Frederico
AU - Kim, JangKeun
AU - Klosinska, Aleksandra
AU - Kubik, Angela
AU - Lee, Han Chung
AU - Li, Yinghui
AU - Li, Zhongwang
AU - Lucarelli, Nicholas
AU - Lynham, Steven
AU - Marullo, Anthony
AU - Mason, Christopher
AU - Matei, Irina
AU - Meydan, Cem
AU - Mimar, Sayat
AU - Mohamed-Ali, Vidya
AU - Muratani, Masafumi
AU - Naglah, Ahmed
AU - Nelson, Charlotte
AU - Nestler, Kevin
AU - Nicod, Jerome
AU - O'Shaughnessy, Kevin
AU - De Oliveira, Lorraine Christine
AU - Oswalt, Leah
AU - Overbey, Eliah
AU - Patel, Vaksha
AU - Patras, Laura Ioana
AU - Polo, San-huei
AU - Rodríguez-Lopez, María
AU - Rodriques, Samuel
AU - Roufosse, Candice
AU - Sadeghi-Alavijeh, Omid
AU - Sanchez-Hodge, Rebekah
AU - Sanders, Lauren M.
AU - Sankar, Anindya
AU - Sarder, Pinaki
AU - Schisler, Jonathan
AU - Schittenhelm, Ralf B.
AU - Schweickart, Annalise
AU - Scott, Ryan
AU - Shiba, Dai
AU - Lim, Terry
AU - Silveira, Willian
AU - Slawinski, Hubert
AU - Smith, Scott
AU - Snell, Daniel
AU - Sosa, Julio
AU - Steele, Joel
AU - Tabetah, Marshall
AU - Tanuwidjaya, Erwin
AU - Uruno, Akira
AU - Vaughan, Michael
AU - Walker-Samuel, Simon
AU - Wan, Elizabeth
AU - Yamamoto, Masayuki
AU - Yang, Xiaoping
AU - Yasmin, Yasmin
AU - Yun, Sanghee
AU - Zhang, Hailey
AU - Dai, Zhongquan
AU - Zimmermann, Jasminka
AU - Zwart, Sara
AU - Almeida, Eduardo A.C.
AU - Zhong, Chutong
PY - 2023/10/11
Y1 - 2023/10/11
N2 - Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.
AB - Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored.We performed biomolecular (epigenomic, transcriptomic, proteomic, epiproteomic, metabolomic, metagenomic), clinical chemistry (electrolytes, endocrinology, biochemistry) and morphometry (histology, 3D imaging, miRNA-ISH, tissue weights) analyses using samples and datasets available from 11 spaceflight-exposed mouse and 5 human, 1 simulated microgravity rat and 4 simulated GCR-exposed mouse missions.We found that spaceflight induces: 1) renal transporter dephosphorylation which may indicate astronauts’ increased risk of nephrolithiasis is in part a primary renal phenomenon rather than solely a secondary consequence of bone loss; 2) remodelling of the nephron that results in expansion of distal convoluted tubule size but loss of overall tubule density; 3) renal damage and dysfunction when exposed to a Mars roundtrip dose-equivalent of simulated GCR.
U2 - 10.21203/rs.3.rs-2982830/v1
DO - 10.21203/rs.3.rs-2982830/v1
M3 - Other contribution
PB - Research Square
ER -
Walsh S, Siew K, Afsari F, Al-Jaber M, Allen N, Al-Maadheed M et al. Cosmic Kidney Disease: The Effects of Spaceflight and Galactic Cosmic Radiation on Renal Structure and Function. 2023. 22 p. doi: 10.21203/rs.3.rs-2982830/v1